Estimating Per-Locus Mutation Rates
نویسنده
چکیده
Relative per-locus mutation rates for Y-DNA microsatellites, and also for mitochondrial DNA singlenucleotide polymorphisms, can be estimated directly from diverse collections of haplotypes without segregating population components. The calibrated average mutation rates for the FTDNA panels of 12, 25, and 37 loci are 0.00187±0.00028, 0.00278±0.00042, and 0.00492±0.00074, respectively, from a collection of haplotypes from Y-Search. The individual per-locus rates are given here.
منابع مشابه
Towards Improvements in the Estimation of the Coalescent: Implications for the Most Effective Use of Y Chromosome Short Tandem Repeat Mutation Rates
Over the past two decades, many short tandem repeat (STR) microsatellite loci on the human Y chromosome have been identified together with mutation rate estimates for the individual loci. These have been used to estimate the coalescent age, or the time to the most recent common ancestor (TMRCA) expressed in generations, in conjunction with the average square difference measure (ASD), an unbiase...
متن کاملEstimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae.
Although mutation rates are a key determinant of the rate of evolution they are difficult to measure precisely and global mutations rates (mutations per genome per generation) are often extrapolated from the per-base-pair mutation rate assuming that mutation rate is uniform across the genome. Using budding yeast, we describe an improved method for the accurate calculation of mutation rates base...
متن کاملEstimates of Cellular Mutagenesis From Cosmic Rays
A parametric track structure model is used to estimate the cross section as a function of particle velocity and charge for mutations at the HGPRT locus in human broblast cell cultures . Experiments that report the fraction of mutations per surviving cell for human lung and skin broblast cells indicate small di erences in the mutation cross section for these two cell lines when di erences in ina...
متن کاملGenetic analysis of children of atomic bomb survivors.
Studies are under way for the detection of potential genetic effects of atomic bomb radiation at the DNA level in the children of survivors. In a pilot study, we have examined six minisatellites and five microsatellites in DNA derived from 100 families including 124 children. We detected a total of 28 mutations in three minisatellite loci. The mean mutation rates per locus per gamete in the six...
متن کاملMutation rate in human microsatellites: influence of the structure and length of the tandem repeat.
In 10,844 parent/child allelic transfers at nine short-tandem-repeat (STR) loci, 23 isolated STR mismatches were observed. The parenthood in each of these cases was highly validated (probability >99.97%). The event was always repeat related, owing to either a single-step mutation (n=22) or a double-step mutation (n=1). The mutation rate was between 0 and 7 x 10(-3) per locus per gamete per gene...
متن کامل